A scientific study confirms that the presence of IgG antibodies supports the post-infectious nature of MIS-C.

 Multisystem inflammatory syndrome in children (MIS-C) associated with Covid-19 is a rare (before Covid) and serious medical condition. It is characterized by inflammation in various organs. In this context, a research team from the University Children’s Hospital in Damascus conducted a retrospective study, the first of its type in Syria, entitled: “Clinical presentation and management of multisystem inflammatory syndrome in children associated with covid-19: a retrospective observational descriptive study in a pediatric hospital in Syria”.

The scientific study aimed to conduct a comprehensive review and summary of the clinical manifestations, laboratory findings, outcomes, and management of MIS-C cases present in the hospital between May 2020 and October 2021. Data collection involved extracting information from medical records, and patients were identified based on the case definition established by the World Health Organization (WHO). Various laboratory investigations, diagnostic evaluations, clinical presentations, and treatments were performed to assess patients.

A total of 232 COVID-19 cases were reported with COVID-19 infection. Among these cases, 25 (10.77%) were identified as MIS-C. The median age of the patients was 5.5 years, with the majority being male patients (72%). Patients experienced fever (100%), bilateral conjunctivitis (88%), rash (84%), gastrointestinal symptoms (76%), and cardiac dysfunction (72%). Other notable findings included oral cavity changes (64%), edema (36%), cervical lymphadenopathy (36%), and neurological manifestations (28%). Respiratory symptoms were uncommon (16%). All patients recovered, with no recorded deaths.

The study concluded that the predominant presence of positive SARS-CoV-2 IgG in the majority of patients in this study supports the post-infectious nature of MIS-C. Respiratory symptoms were less prevalent in both pediatric COVID-19 and MIS-C patients. Early supportive care is crucial in management.